Oral contraception and the effect on thrombosis in premenopausal women: a review of randomised controlled trials
Item
- Title
- Oral contraception and the effect on thrombosis in premenopausal women: a review of randomised controlled trials
- Author(s)
- Schaefer, K
- Abstract
- Background Thrombosis represents a leading cause of morbidity and mortality worldwide. Oral contraceptives (OCs) are thought to be an independent risk factor. Although various epidemiological and case control studies have been conducted, at this point in time, there is still uncertainty about the haemostatic parameters related to the risk of thrombogenicity in women who take oral contraceptives. Objective This study was conducted to evaluate whether changes of levels of haemostatic parameters in young healthy women following OC administration lead to an increased risk of thrombogenicity. Furthermore, to inform clinical practice whether safety measures may be appropriate before administration. Design Structured literature review. Methods Electronic databases were searched for appropriate studies relevant to the research question, published between 2011-2019, in adherence to the inclusion/-exclusion criteria applying Boolean logic. Data regarding characteristics and outcomes of included studies was extracted. A methodological quality assessment of the included studies was performed using the CONSORT item list, SORT tool, EVAT tool and the SJR indicator. Results A total of eleven studies matched all the inclusion criteria and were included in the final review. Across the scoring systems used, overall high reporting and journal prestige but low methodological quality and external validity was determined. The reviewed studies included primarily Caucasian females in their 20’s. Discussion Overall, the 3rd generation pill DG/EE showed to carry the highest thrombogenic risk followed by the 2nd generation OC EE/LNG which showed to carry higher thrombogenic risk than newer generation pills E2/NOMAC and E2V/DNG. However, interpretation of study findings was restricted by heterogeneity in interventions, control groups and outcome measures. Application of the results to real life scenario was impeded by the lack of reporting of clinical effect size. Conclusion This review reflects the limitations in the quality of the literature investigating the relation between VTE risk and OC use. Although, changes in levels of haemostatic parameters in premenopausal women following OC administration may lead to an increased risk of thrombogenicity, further research establishing clinical implications for patients as well as the need of safety measures before administration of OCs is warranted.
- presented at
- European School of Osteopathy
- Date Accepted
- 2020
- Date Submitted
- 28.10.2020 18:08:19
- Type
- osteo_thesis
- Language
- English
- Submitted by:
- 62
- Pub-Identifier
- 16690
- Inst-Identifier
- 1229
- Keywords
- Oral contraception, Combined oral contraception, Venous thromboembolism, Haemostatic parameter, Coagulation
- Recommended
- 0
- Item sets
- Thesis
Schaefer, K, “Oral contraception and the effect on thrombosis in premenopausal women: a review of randomised controlled trials”, Osteopathic Research Web, accessed May 4, 2025, https://www.osteopathicresearch.com/s/orw/item/165