Evidence on the effect of manually applied forces on the cell physiology in connective tissue; a systematic narrative review
Item
- Title
- Evidence on the effect of manually applied forces on the cell physiology in connective tissue; a systematic narrative review
- Title
- Evidence on the effect of manually applied forces on the cell physiology in connective tissue; a systematic narrative review
- Author(s)
- Jung-Adams Beatrix
- Abstract
- Background: Connective tissue (CT) cells including fibroblasts are involved during an inflammatory response with mechanical forces influencing cellular interactions, apparent both in injury and during the repair process. Little evidence is currently available of how manual therapy (MT) affects these cellular interactions. Objective: To evaluate and objectively appraise the physiological evidence-based literature on the effect of manually applied forces on CT cells, by assessing their methodological quality with the aim to explain how MT may support repair. Method: A systematic literature search was performed using a variety of computer-based databases as well as manual searches for relevant articles fulfilling the inclusion criteria, which were sorted by study designs, ranked according to the hierarchy of evidence and appraised with criteria appropriate to each study type. Results: The quality of the majority of literature assessed (n = 26) was low due to the subject matter being physiology, which was ranked low in the hierarchy of evidence and poor methodology. Conclusion: The highest-quality studies demonstrated that MT affected CT cell structure, their proliferation rate and associated immunological cell response. There was little indication of how the laboratory testing could be translated to a clinical setting. Future research needs improved methodology and interventions that are more representative of MT to inform manual therapists, including osteopaths, of the most suitable treatment options to improve CT repair.
- Abstract
- Background: Connective tissue (CT) cells including fibroblasts are involved during an inflammatory response with mechanical forces influencing cellular interactions, apparent both in injury and during the repair process. Little evidence is currently available of how manual therapy (MT) affects these cellular interactions. Objective: To evaluate and objectively appraise the physiological evidence-based literature on the effect of manually applied forces on CT cells, by assessing their methodological quality with the aim to explain how MT may support repair. Method: A systematic literature search was performed using a variety of computer-based databases as well as manual searches for relevant articles fulfilling the inclusion criteria, which were sorted by study designs, ranked according to the hierarchy of evidence and appraised with criteria appropriate to each study type. Results: The quality of the majority of literature assessed (n = 26) was low due to the subject matter being physiology, which was ranked low in the hierarchy of evidence and poor methodology. Conclusion: The highest-quality studies demonstrated that MT affected CT cell structure, their proliferation rate and associated immunological cell response. There was little indication of how the laboratory testing could be translated to a clinical setting. Future research needs improved methodology and interventions that are more representative of MT to inform manual therapists, including osteopaths, of the most suitable treatment options to improve CT repair.
- presented at
- British School of Osteopathy
- Date Accepted
- 2011
- Date Submitted
- 3.2.2012 00:00:00
- Type
- osteo_thesis
- Language
- English
- Pub-Identifier
- 15066
- Inst-Identifier
- 780
- Keywords
- Connective tissue cells; Physiology; Fibroblasts; Chondrocytes; Cartilage cells; Manual therapy; Osteopathy; Chiropractic; Physiotherapy; Massage; Musculoskeletal manipulations
- Recommended
- 0
- Item sets
- Thesis
Jung-Adams Beatrix, “Evidence on the effect of manually applied forces on the cell physiology in connective tissue; a systematic narrative review”, Osteopathic Research Web, accessed May 14, 2024, https://www.osteopathicresearch.com/s/orw/item/1770